diff --git a/invesalius/data/slice_.py b/invesalius/data/slice_.py
index 633da4a..567ea77 100644
--- a/invesalius/data/slice_.py
+++ b/invesalius/data/slice_.py
@@ -93,8 +93,9 @@ class Slice(object):
         self._type_projection = const.PROJECTION_NORMAL
         self.n_border = const.PROJECTION_BORDER_SIZE
 
-        self.spacing = (1.0, 1.0, 1.0)
+        self._spacing = (1.0, 1.0, 1.0)
         self.rotations = (0, 0, 0)
+        self.center = [0, 0, 0]
 
         self.number_of_colours = 256
         self.saturation_range = (0, 0)
@@ -125,6 +126,16 @@ class Slice(object):
         i, e = value.min(), value.max()
         r = int(e) - int(i)
         self.histogram = np.histogram(self._matrix, r, (i, e))[0]
+        self.center = [(s * d/2.0) for (d, s) in zip(self.matrix.shape[::-1], self.spacing)]
+
+    @property
+    def spacing(self):
+        return self._spacing
+
+    @spacing.setter
+    def spacing(self, value):
+        self._spacing = value
+        self.center = [(s * d/2.0) for (d, s) in zip(self.matrix.shape[::-1], self.spacing)]
 
     def __bind_events(self):
         # General slice control
@@ -568,16 +579,16 @@ class Slice(object):
                 number_slices = 1
 
             if np.any(self.rotations):
-                dz, dy, dx = self.matrix.shape
+                cx, cy, cz = self.center
                 rx, ry, rz = self.rotations
                 sx, sy, sz = self.spacing
-                T0 = transformations.translation_matrix((-dz/2.0 * sz, -dy/2.0 * sy, -dx/2.0 * sx))
+                T0 = transformations.translation_matrix((-cz, -cy, -cx))
                 Rx = transformations.rotation_matrix(rx, (0, 0, 1))
                 Ry = transformations.rotation_matrix(ry, (0, 1, 0))
                 Rz = transformations.rotation_matrix(rz, (1, 0, 0))
                 #  R = transformations.euler_matrix(rz, ry, rx, 'rzyx')
                 R = transformations.concatenate_matrices(Rx, Ry, Rz)
-                T1 = transformations.translation_matrix((dz/2.0 * sz, dy/2.0 * sy, dx/2.0 * sx))
+                T1 = transformations.translation_matrix((cz, cy, cx))
                 M = transformations.concatenate_matrices(T1, R.T, T0)
 
 
diff --git a/invesalius/data/styles.py b/invesalius/data/styles.py
index 5da1975..4873ebd 100644
--- a/invesalius/data/styles.py
+++ b/invesalius/data/styles.py
@@ -1417,7 +1417,12 @@ class ReorientImageInteractorStyle(DefaultInteractorStyle):
         self.line1 = None
         self.line2 = None
 
+        self.actors = []
+
+        self.picker = vtk.vtkWorldPointPicker()
+
         self.AddObserver("KeyPressEvent", self.OnKeyPress)
+        self.AddObserver("MouseMoveEvent", self.OnMouseMove)
         self.viewer.slice_data.renderer.AddObserver("StartEvent", self.OnUpdate)
 
     def SetUp(self):
@@ -1425,6 +1430,10 @@ class ReorientImageInteractorStyle(DefaultInteractorStyle):
         self.draw_lines()
         Publisher.sendMessage('Reload actual slice')
 
+    def CleanUp(self):
+        for actor in self.actors:
+            self.viewer.slice_data.renderer.RemoveActor(actor)
+
     def OnKeyPress(self, evt, obj):
         key = self.viewer.interactor.GetKeyCode()
         if key == '+':
@@ -1452,10 +1461,46 @@ class ReorientImageInteractorStyle(DefaultInteractorStyle):
         self.viewer.slice_.current_mask.clear_history()
         Publisher.sendMessage('Reload actual slice')
 
+    def OnMouseMove(self, obj, evt):
+        """
+        This event is responsible to reorient image, set mouse cursors
+        """
+        # Getting mouse position
+        iren = self.viewer.interactor
+        mx, my = iren.GetEventPosition()
+
+        # Getting center value
+        center = self.viewer.slice_.center
+        coord = vtk.vtkCoordinate()
+        coord.SetValue(center)
+        cx, cy = coord.GetComputedDisplayValue(self.viewer.slice_data.renderer)
+
+        dist_center = ((mx - cx)**2 + (my - cy)**2)**0.5
+
+        if dist_center <= 15:
+            cursor = wx.StockCursor(wx.CURSOR_SIZENESW)
+
+            if self.left_pressed:
+                self.picker.Pick(mx, my, 0, self.viewer.slice_data.renderer)
+                x, y, z = self.picker.GetPickPosition()
+                icx, icy, icz = self.viewer.slice_.center
+
+                if self.viewer.orientation == 'AXIAL':
+                    self.viewer.slice_.center = (x, y, icz)
+                elif self.viewer.orientation == 'CORONAL':
+                    self.viewer.slice_.center = (x, icy, z)
+                elif self.viewer.orientation == 'SAGITAL':
+                    self.viewer.slice_.center = (icx, y, z)
+                Publisher.sendMessage('Update slice viewer')
+        else:
+            cursor = wx.StockCursor(wx.CURSOR_DEFAULT)
+
+        self.viewer.interactor.SetCursor(cursor)
+
     def OnUpdate(self, obj, evt):
         w, h = self.viewer.slice_data.renderer.GetSize()
 
-        center = self.viewer.slice_data.actor.GetCenter()
+        center = self.viewer.slice_.center
         coord = vtk.vtkCoordinate()
         coord.SetValue(center)
         x, y = coord.GetComputedDisplayValue(self.viewer.slice_data.renderer)
@@ -1488,6 +1533,8 @@ class ReorientImageInteractorStyle(DefaultInteractorStyle):
 
         self.viewer.slice_data.renderer.AddActor(actor)
 
+        self.actors.append(actor)
+
         return line
 
     def draw_lines(self):
--
libgit2 0.21.2